“Learning the Lingo”

Constraint Lingo

Levelling the lingo playing field.

W ith an ever-declining number of papers written in languages other than English, the idiom of Shakespeare is, today more than ever before, the international language of science [1,2]. In 2014, according to PubMed’s language filter, 95.4% of life science publications retrieved by the search engine were written in English, in line with the trend of the last several decades [1,2]. Today, among th...

Argument Optionality in the LinGO Grammar Matrix

We present a library of implemented HPSG analyses for argument optionality based on typological studies of this phenomenon in the world’s languages, developed in the context of a grammar customization system that pairs a crosslinguistic core grammar with extensions for non-universal phenomena on the basis of user input of typological properties. Our analyses are compatible with multiple interse...

Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy.

Multiple sclerosis (MS) is an autoimmune-inflammatory disease of the central nervous system (CNS) with prominent demyelination and axonal injury. While most MS therapies target the immunologic response, there is a large unmet need for treatments that can promote CNS repair. LINGO-1 (leucine-rich repeat and Ig-containing Nogo receptor interacting protein-1) is a membrane protein selectively expr...

Constraint Lingo : Towards high - level